ArticleMedical journal of the Islamic Republic of Iran2026
Leptin Insensitivity in NAFLD Is Produced by Oxidative Stress and Cytokine Overexpression.
Article in Medical journal of the Islamic Republic of Iran, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) pathogenesis is caused by an imbalance in the biochemistry and immunology of the liver. The aim of the present study was to evaluate the role of oxidative stress and inflammatory factors in the serum concerning leptin concentration. Methods: This study was carried out on 67 females, including 20 healthy and 47 patients diagnosed by liver scan. Anthropometric analysis and routine biochemical tests, including alanine and aspartate transaminase, triglycerides, cholesterol, fasting blood sugar, low-density lipoprotein, high-density lipoprotein, and their ratio, were carried out. Also, the concentration of malondialdehyde and total antioxidant capacity concentration as well as the activity of catalase, superoxide dismutase, and glutathione peroxidase, were estimated. In addition, the concentration of leptin, interleukin-6, and tumor necrosis factor-α was analyzed. Data were analyzed using one-way ANOVA followed by Tukey's post-hoc test, with Results: Patients with NAFLD had significantly higher BMI (33.63±6.37 kg/m² vs. 25.33±2.53 kg/m²), waist circumference (90.6±9.85 cm vs. 81.38±5.44 cm), and hip circumference (93.43±10.06 cm vs. 86.14±5.57 cm) compared with controls ( Conclusion: Although leptin controls fat metabolism via satiety, results revealed that the overproduction of leptin might be a consequence of oxidative stress and inflammatory response to fat accumulation in the liver. Therefore, measuring leptin along with IL-6 and TNF-α might help to diagnose liver injury.
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