Evidence map›Paper›PMID 42894691›Full record

ReviewiScience2026

Harnessing hydrogel technology for advanced periodontitis therapy: A multifunctional approach to oral health restoration.

Xiaoqing Zhuo, Shaoqiang Wang, Li-Yuan Liu, Minmin Zhu, Zhenjiang Zhang, Yuqi Zhou, Maoshan Wang, Xudong Deng, Yanxia Miao, Niannian Li and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoqing ZhuoSchool of Stomatology, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Shaoqiang WangWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Li-Yuan LiuSchool of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi 710129, China.
Minmin ZhuWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Zhenjiang ZhangWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Yuqi ZhouWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Maoshan WangWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Xudong DengSchool of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi 710129, China.
Yanxia MiaoWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Niannian LiWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Xue-Ting WangWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province 261000, China.
Hongguang ZhuSchool of Stomatology, Shandong Second Medical University, Weifang, Shandong Province 261000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a bacterially driven inflammatory disease that can lead to tooth mobility and tooth loss. Conventional non-surgical therapy, antibiotics, and surgery may be limited by residual subgingival biofilms, antimicrobial resistance, and variable clinical outcomes. This review synthesizes recent studies of hydrogel-based systems for local periodontal therapy, focusing on stimuli-responsive release mechanisms, cargo-loading approaches, and regenerative outcomes in relevant animal models. Across these studies, hydrogels function as localized delivery matrices that can prolong retention at periodontal defects, regulate therapeutic exposure, and support tissue repair. We further evaluate translational considerations, including degradation behavior, long-term

Indexed as

antibacterialanti-inflammatorybioactive materialsclinical translationdrug deliveryhydrogelminimally invasive therapyperiodontitisstimuli-responsive hydrogeltissue regeneration

Identifiers

PMID42894691
PMCPMC13676726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.