Evidence map›Paper›PMID 42894666›Full record

ArticleAmerican heart journal plus : cardiology research and practice2026

Proteomic markers associated with blood pressure, hypertension, and treatment-resistant hypertension.

Anna Dieden, Olle Melander, Manan Pareek, Lennart Råstam, Ulf Lindblad, Petri Gudmundsson, Bledar Daka, Margrét Leósdóttir, Peter M Nilsson, Michael H Olsen and 2 more

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Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna DiedenDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Manan PareekCenter for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lennart RåstamDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Ulf LindbladInstitute of Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Petri GudmundssonDepartment of Biomedical Science, Malmö University, Sweden.
Bledar DakaInstitute of Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Margrét LeósdóttirDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Peter M NilssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Michael H OlsenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Amra JujicDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Martin MagnussonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study was to investigate associations between 92 proteins and blood pressure (BP), prevalent hypertension (HT) and apparent treatment-resistant HT (aTRH) in a population-derived sub cohort. Methods: Excluding subjects with atherosclerotic cardiovascular disease (ASCVD) ( Results: Complete data was available in 1527 individuals (mean age 67.1 ± 6.0 years; 30.5% women). Interleukin-1 receptor type 2 (IL1R2) associated with systolic BP (β 2.79, p 0.008), diastolic BP (β 1.78, Conclusions: Among 1527 individuals without established ASCVD, IL1R2 was associated with systolic and diastolic blood pressure, as well as with both HT and aTRH, while CHI3L1 associated with systolic blood pressure and prevalent HT. These findings may offer novel insights and inspire future research on HT and inflammation.

Indexed as

aTRHBlood pressureCHI3L1HypertensionIL1R2Proteomics

Identifiers

PMID42894666
PMCPMC13676905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.