ArticleJournal of pain research2026
Mild Moxibustion Alleviates Primary Dysmenorrhea in Rats Through TRPV1-Associated Modulation of NF-κB Signaling and Uterine Oxidative Stress.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the therapeutic effect and analgesic mechanism of mild moxibustion at Shenque (CV8) and Guanyuan (CV4) in a primary dysmenorrhea (PD) rat model, focusing on the involvement of TRPV1-NF-κB signaling and uterine oxidative stress. Methods: Forty female Sprague-Dawley (SD) rats were randomly divided into five groups (n=8): blank group (BG), model group (MG), mild moxibustion group (MMG), antagonist capsazepine group (CPZG), and ibuprofen group (IG). PD models were established through cold stimulation combined with estradiol benzoate and oxytocin injection. The MMG received mild moxibustion at "Shenque" (CV8) and "Guanyuan" (CV4) acupoints. The CPZG was pretreated with capsazepine (CPZ) before moxibustion. The IG received ibuprofen via gavage. After intervention, pain thresholds and writhing scores were measured; uterine pathology was observed via HE staining; ELISA, colorimetric assay, immunohistochemistry (IHC), and Western blotting were used to detect relevant biomarkers. Results: Mild moxibustion significantly elevated pain thresholds and reduced writhing scores (vs MG, Conclusion: Mild moxibustion at CV8 and CV4 alleviates PD in rats through mechanisms involving TRPV1 activation, NF-κB pathway modulation, and improvement of uterine oxidative stress. These findings provide a preclinical basis for further investigation.
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