ArticleCureus2026
Incidence and Progression of Acute Kidney Injury Following Head and Neck Surgeries for COVID-19-Associated Mucormycosis: A Prospective Observational Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOVID-19-associated mucormycosis (CAM) surged because of the combination of systemic corticosteroids, poorly controlled diabetes mellitus, and altered host immunity. Rhino-orbito-cerebral mucormycosis (ROCM) requires extensive surgical debridement and systemic nephrotoxic liposomal amphotericin B (L-AMB) therapy. This study evaluated the incidence, temporal course, and association of postoperative acute kidney injury (AKI) with various clinical factors in this high-risk surgical cohort. MATERIALS AND
methodsThis prospective observational cohort study enrolled 49 adult patients who underwent major head and neck surgical debridement for ROCM and required postoperative critical care management. We excluded patients with established renal failure. We performed and recorded serial clinical and biochemical monitoring daily over the next five days. AKI incidence and severity were staged according to Acute Kidney Injury Network (AKIN) criteria.
resultsA total of 49 patients were evaluated for AKI, of which 9 developed AKI (18.4%). Patients who developed AKI had a higher mean age (56.6 ± 10.0 years versus 49.4 ± 10.3 years) and preoperative serum creatinine (1.1 ± 0.5 vs 0.9 ± 0.2 mg/dL), but these differences were not statistically significant. However, patients who developed post-operative AKI had a significantly lower estimated glomerular filtration rate (eGFR) (87.4 ± 27.1 vs 102.9 ± 17.4 mL/min/1.73 m²; p = 0.03), and a significantly higher prevalence of AKI was found in patients having pre-existing hypertension (77.8% vs. 32.5%; p = 0.02). Conversely, mean duration (p = 0.35), cumulative preoperative L-AMB dose (p = 0.319), and background diabetes mellitus (p = 0.136) did not differ significantly between groups.
conclusionAKI was noted in nearly one-fifth of patients after ROCM surgery and was more common in older patients with hypertension and poorer baseline renal function. Baseline renal function appeared more important than cumulative L-AMB exposure or diabetes, highlighting the need for early renal risk assessment and close postoperative monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.