Evidence map›Paper›PMID 42894580›Full record

ArticleMolecular therapy. Nucleic acids2026

RNA-encoded PGT121-LS anti-HIV antibody: Comprehensive preclinical characterization and translational pharmacokinetics.

Felix Tolksdorf, Johannes Nelke, Robin Johannson, Janina Caesar, Anuhar Chaturvedi, Anja Kopp, Leyla Fischer, Alexandra Malz, Sven Kratochvil, Imke Gerhard and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Felix TolksdorfBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Johannes NelkeBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Robin JohannsonBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Janina CaesarBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Anuhar ChaturvediBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Anja KoppBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Leyla FischerBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Alexandra MalzBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Sven KratochvilBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Imke GerhardBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Jan P BogenBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Candice MorinBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Maximilian KullmannBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Michael S SeamanCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Boston, MA 02115, USA.
Georgia D TomarasCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University Medical Center, 300 N. Duke Street, Durham, NC 27701, USA.
Nicole L YatesCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University Medical Center, 300 N. Duke Street, Durham, NC 27701, USA.
Margaret E AckermanThayer School of Engineering, Dartmouth College, 14 Engineering Dr, Hanover, NH 03755, USA.
Joshua A WeinerThayer School of Engineering, Dartmouth College, 14 Engineering Dr, Hanover, NH 03755, USA.
Ursula EllinghausBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Christiane R StadlerBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Uğur ŞahinBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.
Valentin Le DouceBioNTech SE, An der Goldgrube 12, 55131 Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus (HIV)-1 broadly neutralizing antibodies (bNAbs) have demonstrated clinical efficacy but face manufacturing challenges associated with recombinant protein production and purification. Here, we present a ribonucleic acid (RNA)-encoded bNAb (RibobNAb) platform that enables

Indexed as

bNAbHIVHIV neutralizationMT: Oligonucleotides: Therapies and ApplicationsNHPPGT121pharmacokineticsRibobNAbRiboMabRNA-encoded antibody

Identifiers

PMID42894580
PMCPMC13676711

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.