ArticleEULAR rheumatology open2026
Multifactorial lifestyle interventions in rheumatoid arthritis: a systematic literature review.
Article in EULAR rheumatology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Although research investigating the role of lifestyle factors in rheumatoid arthritis (RA) management is growing, evidence regarding multifactorial lifestyle interventions remains limited. The aim of this systematic review is to examine the evidence on multifactorial lifestyle interventions for adults with RA and their effects on disease activity, inflammatory markers, fatigue, physical function, pain, and quality of life. Methods: Five databases (PubMed, SPORTdiscus, Embase, Medline, and CINAHL) were searched in February 2024 and June 2026 to retrieve clinical trials investigating lifestyle interventions in adults with RA on disease activity, inflammatory markers, pain, function, fatigue, and quality of life. Risk of bias was assessed using the Cochrane Risk of Bias tool. Key study data were extracted, and because of study heterogeneity, results were synthesised narratively. Results: Of 2992 screened records, 12 studies met the inclusion criteria, including a total of 660 participants. Some studies demonstrated significant and clinically important improvements in outcome measures; however, findings varied across studies and outcome measures. Two studies demonstrated potential advantages of multifactorial lifestyle interventions over single-component interventions. Conclusions: Multifactorial lifestyle interventions may improve disease activity and other core outcome measures in adults. However, findings were inconsistent across studies, with interpretation limited by varying baseline characteristics, small sample sizes, methodological limitations, and low-certainty evidence. Larger, high-quality trials are needed to confirm these findings and evaluate the effectiveness, feasibility, acceptability, and implementation of multifactorial lifestyle interventions in RA management.
Identifiers
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Registered trials
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