ArticleRedox report : communications in free radical research2026
Protein disulphide isomerase protects against ALS/FTD phenotypes associated with cyclin F in zebrafish and cellular models.
Sina Shadfar, Sonam Parakh, Emma Perri, Cyril Jones Jagaraj, Sara Assar Kashani, Keelin Beyers, Audrey M G Ragagnin, Angela S Laird, Julie D Atkin
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In one paragraphArticle in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Sina ShadfarMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.ORCID 0000-0001-7626-1096 Sonam ParakhMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.ORCID 0000-0002-7048-9695 Emma PerriMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Cyril Jones JagarajMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Sara Assar KashaniMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Keelin BeyersMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Audrey M G RagagninMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Angela S LairdMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.ORCID 0000-0002-6860-9192 Julie D AtkinMotor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.ORCID 0000-0003-2427-499X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundMutations in
objectivesTo test whether PDI overexpression prevents the cellular and behavioural phenotypes induced by the ALS/FTD-associated cyclin F
methodsNeuro-2a cells were co-transfected with mCherry-tagged wild-type or mutant cyclin F
resultsMutant cyclin F
conclusionPDI protects against ALS/FTD-associated mutant cyclin F in both cellular and
Indexed as
Amyotrophic Lateral SclerosisCyclinsFrontotemporal DementiaProtein Disulfide-IsomerasesAnimalsAnimals, Genetically ModifiedApoptosisEndoplasmic Reticulum StressHumansMutationPhenotypeZebrafishCCNF protein, humanCyclinsProtein Disulfide-IsomerasesageingCCNFcyclin FER stressFTDMNDneurodegenerationproteostasiszebrafish
Identifiers
PMID42894325
PMCPMC13686195
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