Evidence map›Paper›PMID 42894313›Full record

ArticleOncoimmunology2026

Glioblastoma immune landscape remodeling following treatment with CD70-targeted CAR-T cells.

Alexandros Kourtesakis, Dennis Alexander Agardy, Clara Tejido Dierssen, Ling Hai, Dirk Carsten Frieder Hoffmann, Normann Mussnig, Ralph Sinn, Manuel Fischer, Andy Schacht, Michael Breckwoldt and 5 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexandros KourtesakisClinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dennis Alexander AgardyClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Clara Tejido DierssenClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ling HaiClinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dirk Carsten Frieder HoffmannClinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Normann MussnigClinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ralph SinnDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Manuel FischerDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Andy SchachtClinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michael BreckwoldtDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Lukas BunseClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tim SauerMedicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
Michael PlattenClinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Wolfgang WickClinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tobias KesslerClinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimeric antigen receptor (CAR)-T cell therapy has shown limited efficacy in glioblastoma (GB), largely because of the immunosuppressive tumor microenvironment (TME). We have previously demonstrated that the ligand-based mCD70-directed construct mCAR27 specifically eliminates CD70⁺ GB cells

Indexed as

Brain NeoplasmsCD27 LigandGlioblastomaImmunotherapy, AdoptiveReceptors, Chimeric AntigenAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansLymphocytes, Tumor-InfiltratingMiceTumor MicroenvironmentCD27 LigandCD70 protein, humanReceptors, Chimeric AntigenCAR-T cellsCD70GlioblastomaimmunotherapyscRNAseq

Identifiers

PMID42894313
PMCPMC13682394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.