Evidence map›Paper›PMID 42894265›Full record

ArticleChemMedChem2026

Tuning the Triazolotriazine Scaffold Toward Selective A

Veronika Kost, Filippo Prencipe, Federica Panozzi, Veronica Salmaso, Sonja Kachler, Karl-Norbert Klotz, Elisabetta Coppi, Simone Adorinni, Stefano Moro, Anna Maria Pugliese and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Veronika KostDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
Filippo PrencipeDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
Federica PanozziDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.ORCID https://orcid.org/0009-0000-6850-5097
Veronica SalmasoMolecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Sonja KachlerRudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Karl-Norbert KlotzInstitut für Pharmakologie und Toxikologie, University of Würzburg, Würzburg, Germany.
Elisabetta CoppiDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-4434-5919
Simone AdorinniDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0002-6888-7635
Stefano MoroMolecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0002-7514-3802
Anna Maria PuglieseDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Stephanie FedericoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0003-2800-5287
Giampiero SpallutoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0002-1957-7155
Tatiana Da RosDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 2,5,7-trisubstituted [1,2,4]triazolo[1,5-a][1,3,5]triazines (TTs) was developed to identify selective A

Indexed as

Adenosine A3 Receptor AntagonistsNeuroprotective AgentsReceptor, Adenosine A3TriazinesTriazolesAnimalsHippocampusHumansMolecular Docking SimulationMolecular StructureRatsStructure-Activity RelationshipAdenosine A3 Receptor AntagonistsNeuroprotective AgentsReceptor, Adenosine A3TriazinesTriazolesA3 adenosine receptoradenosine receptorsG protein‐coupled receptor (GPCR) antagonistsischemiaoxygen glucose deprivation (OGD)

Identifiers

PMID42894265
PMCPMC13677798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.