ArticleBMC oral health2026
Micro-CT analysis of calcium silicate-based cements in simulated acidic and neutral environments: a comparative study.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
backgroundThis in vitro investigation aimed to examine the physical characteristics of three calcium silicate-based cements-Neo MTA Plus, Biodentine, and MTA Repair HP-when used as root canal filling materials under diverse environmental conditions, employing micro-computed tomography (micro-CT) analysis.
methodsA total of 144 extracted human maxillary anterior teeth were sectioned to produce standardized root canals. These canals were then randomly distributed into 12 groups (n = 12) according to the type of material used, the method of placement (either manual or ultrasonic), and the storage environment (acidic or phosphate-buffered saline [PBS]). Phosphate-buffered saline (PBS, pH ≈ 7.4) served as the neutral comparison condition referred to in the title. The materials were inserted into the prepared canals and underwent micro-CT scanning both before and after a 7-day exposure to the designated environments. The resulting changes in volume, density, and porosity were measured. Data normality was assessed with the Shapiro-Wilk test. As the data were non-parametric, Kruskal-Wallis and Dunn's post hoc tests were used (p < 0.05).
resultsUnder acidic conditions, a trend toward structural changes was observed in all tested materials. Biodentine exhibited a greater tendency toward volume reduction compared to the other materials; however, these differences were not statistically significant (p > 0.05). Increased porosity was noted under acidic conditions, particularly in Biodentine, whereas specimens stored in phosphate-buffered saline (PBS) showed minimal changes. No statistically significant differences were detected between the acidic and PBS conditions; however, several baseline-to-post-incubation comparisons showed statistically significant differences according to Dunn's post hoc test.
conclusionsWithin the limitations of this study, calcium silicate-based materials showed a tendency toward structural changes under acidic conditions, although these were not always statistically significant. Biodentine exhibited a greater tendency for change compared to the other materials, while placement technique had no significant effect.
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