ArticleArthritis research & therapy2026
Age-dependent effects of TRPA1 deficiency on pain and osteoarthritis pathology following joint injury in mice.
Article in Arthritis research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionTransient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable cation channel expressed in multiple cell types, including nociceptive C-fibers innervating the knee joint, and is activated by mechanical, inflammatory, and oxidative stimuli. While TRPA1 inhibition reduces pain-related behavior in chemically-induced arthritis, its role in mechanically induced osteoarthritis (OA), and how this relationship changes with age, remains unclear. Here we tested the hypothesis that TRPA1 deficiency alters mechanical sensitivity and OA pathology after joint injury in an age-dependent manner in mice.
methodsMale C57BL/6J wildtype (WT) and TRPA1-deficient (TRPA1
resultsIn young mice, TRPA1
conclusionsTRPA1 contributes to early post-injury mechanical sensitivity and gait mechanics following joint injury. TRPA1 deficiency results in altered gait biomechanics and more severe OA development in young mice but not in adult mice. These findings indicate an age-dependent interaction between sensory signaling and joint degeneration, with implications for TRPA1-targeted analgesic strategies in joint disease.
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