Evidence map›Paper›PMID 42894165›Full record

ArticleRespiratory research2026

A novel protective role for SULF1 in chronic obstructive pulmonary disease through systemic compensation and binding to KRT15.

Yu Liu, Erkang Yi, Yue Xi, Yujie Zuo, Hairong Wang, Xiaoyu Wang, Qianmei Wen, Jingwei Zhang, Xinyue Mei, Haiqing Li and 8 more

Abstract read
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In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Yu Liu *State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Erkang Yi *Guangzhou National Laboratory, Guangzhou International BioIsland, No.9 Xing Dao Huan Bei Road, Guangzhou, Guangdong, 510005, China.
Yue Xi *State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Yujie Zuo *State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Hairong WangGuangzhou National Laboratory, Guangzhou International BioIsland, No.9 Xing Dao Huan Bei Road, Guangzhou, Guangdong, 510005, China.
Xiaoyu WangState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Qianmei WenState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Jingwei ZhangState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Xinyue MeiState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Haiqing LiState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Fan WuState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Zihui WangState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Qi WanState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Gaoying TangState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Xiaoyang ZhengState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Ruiting SunState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.
Pixin RanState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China. pxran@gzhmu.edu.cn.
Yumin ZhouState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China. zhouyumin410@126.com.

Funding

Foundation of Guangzhou National Laboratory SRPG22-016Foundation of Guangzhou National Laboratory SRPG22-018National Natural Science Foundation of China 82500053the grant of State Key Laboratory of Respiratory Disease SKLRD-Z-202315the Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0528401
6 · The paper itself

Abstract

This study explores the role of Sulfatase 1 (SULF1) in the progression of Chronic Obstructive Pulmonary Disease (COPD). SULF1, a modifying enzyme involved in various biological processes, was quantified in human serum using ELISA, and its correlation with lung function was analyzed. The in vivo function of SULF1 was investigated through CRISPR-mediated gene knockout (KO) in mice, and SULF1 overexpression was induced via adeno-associated virus (AAV). A COPD model was established by exposing mice to cigarette smoke (CS). Our findings revealed that SULF1 levels were elevated in the serum of COPD patients, where they negatively correlated with the FEV

Indexed as

Pulmonary Disease, Chronic ObstructiveSulfotransferasesAnimalsFemaleHumansLungMaleMiceMice, Inbred C57BLMice, KnockoutProtein BindingSULF1 protein, humanSulf1 protein, mouseSulfotransferasesChronic obstructive pulmonary diseaseKRT15Lung fibroblastsSULF1

Identifiers

PMID42894165
PMCPMC13679013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.