Evidence map›Paper›PMID 42894156›Full record

ArticleBMC oral health2026

Zinc-containing ionic liquid combined with carboxymethyl chitosan for vital pulp therapy in mature permanent teeth with carious pulp exposure.

Zichao Zhou, Hongwei Chen, Chaoli Wang, Anya Liu, Minghao Wang, Chongyang Zhang, Li Fan, Yifang Yuan, Shengchao Wang, Wenkai Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zichao Zhou *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Hongwei Chen *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Chaoli Wang *Department of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Anya LiuThe First Regiment, School of Basic Medicine, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Minghao WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Chongyang ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Li FanDepartment of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Yifang YuanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Yuanyf0331@163.com.
Shengchao WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Wangshengchao@fmmu.edu.cn.
Wenkai JiangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. JiangW6@cardiff.ac.uk.

Funding

Air Force Medical University Third Affiliated Hospital Clinical New Technology Project LX2023-302Air Force Medical University Third Affiliated Hospital Clinical New Technology Project LX2025-302China Postdoctoral Science Foundation 2024M764325general project from State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration 2024MS03Key Research and Development Projects of Shaanxi Province 2025YF-07National Natural Science Foundation of China 82270973National Natural Science Foundation of China 82501128
6 · The paper itself

Abstract

backgroundThe elimination of pulpal infection is critical for the success of vital pulp therapy (VPT) in mature permanent teeth with carious pulp exposure. However, commonly used pulp capping materials often possess inadequate antibacterial properties, which limits treatment success. This study aimed to develop a zinc-containing ionic liquid (IL-Zn)/carboxymethyl chitosan (CMCS) composite and evaluate its potential as an adjunctive pulp capping material for VPT.

methodsIL-Zn was characterized by energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (

resultsEDS, FTIR,

conclusionsThis study developed an IL-Zn with strong antibacterial properties and a low risk of resistance. When combined with CMCS, the composite exhibited favorable antibacterial activity and biocompatibility. Used together with iRoot BP Plus for the treatment of carious pulp exposure in mature permanent teeth, it significantly enhanced pulp healing and dentin repair, offering a promising strategy to improve the success rate of vital pulp therapy.

Indexed as

Anti-Bacterial AgentsChitosanDental CariesDental Pulp CappingDental Pulp ExposureIonic LiquidsPulp Capping and Pulpectomy AgentsZincAnimalsBiofilmsHumansLacticaseibacillus caseiMicrobial Sensitivity TestsMicroscopy, Electron, ScanningSpectroscopy, Fourier Transform InfraredStreptococcus mutansAnti-Bacterial Agentscarboxymethyl-chitosanChitosanIonic LiquidsPulp Capping and Pulpectomy AgentsZincAntimicrobial agentCarboxymethyl chitosanCarious pulp exposureIonic liquidVital pulp therapyZinc

Identifiers

PMID42894156
PMCPMC13678887

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.