ArticleBMC neurology2026
Age-related differences in clinical manifestations, neuroimaging features, and treatment of spontaneous intracranial hypotension: a retrospective cohort study.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe influence of age on the management of spontaneous intracranial hypotension (SIH), particularly epidural blood patch (EBP), remains unclear. This study aims to characterize age-related differences in clinical manifestation, neuroimaging features, and treatment outcomes.
methodsIn this retrospective cohort study, we analyzed 54 SIH patients who underwent EBP at our center. Patients were classified into two groups based on the cohort median age (35 years). Demographic, clinical, neuroimaging features, and treatment outcomes were compared between the two groups. We further utilized Spearman correlation, locally weighted scatterplot smoothing, and multivariable linear regression to analyze the association between age and EBP volume. Several sensitivity analyses were conducted to assess the robustness of our findings.
resultsAmong 54 enrolled patients, the injected volume of EBP was markedly larger in the older group (26.00 [19.12, 32.75] vs. 19.25 [15.00, 24.00] ml, P = 0.018). While Spearman correlation indicated a significant positive correlation existed between age and EBP volume (ρ = 0.388, P = 0.004), subgroup analysis revealed a dissociation: a strong linear correlation in the older group (ρ = 0.458, P = 0.018) contrasted with a non-significant, non-monotonic trend in the younger group (ρ = -0.034, P = 0.863). Linear regression analysis showed that age was positively associated with EBP volume (β = 2.899, 95% confidence interval: 0.475-5.322, P = 0.023).
conclusionThese findings highlight the potential utility of considering patient age when planning EBP procedures, suggesting that age-adapted volume strategies may optimize treatment and warrant further investigation.
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