Evidence map›Paper›PMID 42894090›Full record

ReviewPharmacological reports : PR2026

Nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-), and pyrin domain-containing protein 3 (NLRP3) inflammasome and snake venoms/toxins: mechanisms, pathophysiological relevance, and translational perspectives.

Charles Nunes Boeno, Mauro Valentino Paloschi, Milena Daniela Souza Silva, Juliana Pavan Zuliani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmacological reports : PR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charles Nunes BoenoLaboratory of Cellular Immunology Applied to Health, Fundação Oswaldo Cruz, FIOCRUZ - Rondônia, Rua da Beira, 7671 BR-364, km 3.5, Porto Velho, RO, CEP 76812-245, Brazil.ORCID http://orcid.org/0000-0003-4292-1855
Mauro Valentino PaloschiLaboratory of Cellular Immunology Applied to Health, Fundação Oswaldo Cruz, FIOCRUZ - Rondônia, Rua da Beira, 7671 BR-364, km 3.5, Porto Velho, RO, CEP 76812-245, Brazil.ORCID http://orcid.org/0000-0002-1654-4841
Milena Daniela Souza SilvaLaboratory of Cellular Immunology Applied to Health, Fundação Oswaldo Cruz, FIOCRUZ - Rondônia, Rua da Beira, 7671 BR-364, km 3.5, Porto Velho, RO, CEP 76812-245, Brazil.ORCID http://orcid.org/0000-0002-9309-5111
Juliana Pavan ZulianiLaboratory of Cellular Immunology Applied to Health, Fundação Oswaldo Cruz, FIOCRUZ - Rondônia, Rua da Beira, 7671 BR-364, km 3.5, Porto Velho, RO, CEP 76812-245, Brazil. zuliani.juliana@gmail.com.ORCID http://orcid.org/0000-0001-9221-7749

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 311696/2021-0
6 · The paper itself

Abstract

Snake envenoming triggers a complex inflammatory response that substantially contributes to local tissue destruction and systemic complications. Among the innate immune pathways implicated in venom-induced injury, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-), and pyrin domain-containing protein 3 (NLRP3) inflammasome has emerged as a key sensor-effector platform linking tissue damage, ionic imbalance, reactive oxygen species (ROS), lipid mediators, and cytokine maturation. Experimental studies indicate that crude venoms and isolated snake toxins, including Lys49 and Asp49 phospholipase A

Indexed as

EnvenomingIL-1βInflammationNLRP3 inflammasomePyroptosisSnake venom

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.