ArticleTropical animal health and production2026
Effects of in ovo administration of selenomethionine and vitamin E on hepatic injury in broilers challenged by lipopolysaccharide.
Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigated the effects of in ovo administration of selenomethionine (Se-Met) and vitamin E (VE), individually or in combination, on growth performance, antioxidant capacity, and immune response in broilers challenged by lipopolysaccharide (LPS). A total of 280 fertilized eggs from a yellow-feathered broiler strain were randomly assigned to five groups: Control, LPS, VE + LPS, Se-Met + LPS, and Combo + LPS (VE, Se-Met, and LPS) groups. On embryonic day 10, eggs in the Control and LPS groups received a yolk-sac injection of 0.1 mL saline, whereas those in the VE + LPS, Se-Met + LPS, and Combo + LPS groups were injected with 5 mg VE, 0.02 mg Se-Met, and their combination, respectively. After hatching, all groups except the Control (normal saline) received intraperitoneal injection of 0.3 mg/kg LPS on days 16, 18, and 20 to induce hepatic injury. Results showed that, at 21 days of age, feed conversion ratio (FCR, P = 0.030), serum alanine aminotransferase (ALT, P = 0.003) and tumor necrosis factor-α (TNF-α, P < 0.001) were significantly elevated in the LPS group relative to the Control group, accompanied by hepatic vacuolar degeneration and inflammatory cell infiltration. Conversely, the Combo + LPS group showed significantly improved leg muscle index (P = 0.019) and Newcastle disease virus (NDV) antibody titers (P = 0.041), alongside reduced ALT (P = 0.003) and TNF-α (P < 0.001) levels compared to the LPS group. Histopathological examination revealed that both Se-Met and the combined treatment effectively attenuated LPS-induced hepatic inflammatory infiltration and vacuolar degeneration. In conclusion, in ovo co-administration of Se-Met and VE showed an improving trend for antioxidant capacity, mitigated inflammatory responses, and alleviated LPS-induced hepatic injury in broilers.
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