Evidence map›Paper›PMID 42894044›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Evaluation of antiseptic drug candidate pyridosept in preclinical in vivo toxicity studies.

Renata Kazakova, Alfiya Fakhrieva, Mariya Agafonova, Elena Bulatova, Olga Kirichenko, Albina Malanyeva, Milana Mansurova, Ilnur Ganiev, Natalia Komcharova, Ivan Raginov and 3 more

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Renata KazakovaInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia. RRKazakova@kpfu.ru.ORCID https://orcid.org/0000-0002-2109-569X
Alfiya FakhrievaInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Mariya AgafonovaInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Elena BulatovaInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Olga KirichenkoInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Albina MalanyevaInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Milana MansurovaInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Ilnur GanievInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Natalia KomcharovaInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Ivan RaginovInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Sergey SapozhnikovInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Nikita ShtyrlinInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.
Yurii ShtyrlinInnovative Science and Technology Centre for Pharmaceuticals, Kazan (Volga region) Federal University, Kremlyovskaya St. 18, Kazan, 420008, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to assess the safety profile of the antiseptic drug candidate pyridosept in preclinical in vivo toxicity tests. The safety of pyridosept was assessed in acute toxicity tests in rats, mice and rabbits via dermal, intragastric, intraperitoneal, and inhalation routes of administration. Subchronic dermal toxicity of pyridosept was evaluated following cutaneous application for 90 days in rats and rabbits. Pyridosept was also examined in the accumulation test in rats and in micronucleus assay in the skin and bone marrow of mice after single and repeated administration. Acute oral toxicity study of pyridosept revealed an LD

Indexed as

AntisepticsIn vivoMicronucleus assayPreclinical studiesPyridoseptToxicity

Identifiers

PMID42894044

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.