Evidence map›Paper›PMID 42894023›Full record

ArticlePsychopharmacology2026

Investigation of the pharmacological and circuit basis for psychedelic drug effects on interval timing in mice.

Landon M Klein, Jared Kopelman, Richard F Sharp, Susan B Powell, Mark A Geyer, Jared W Young, Adam L Halberstadt

Abstract read
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Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Landon M KleinDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA.
Jared KopelmanDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA.
Richard F SharpDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA.
Susan B PowellDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA.
Mark A GeyerDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA.
Jared W YoungDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA.
Adam L HalberstadtDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA. ahalberstadt@health.ucsd.edu.

Funding

Investigations into 5-HT2A signaling mechanisms of psychedelic drugs for the treatment of stimulant use disorderR01DA061433 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI ADAM L. Halberstadt, John D McCorvy · 2024 to 2026
$1.5M
NIDA NIH HHS R01 DA061433
6 · The paper itself

Abstract

rationaleClassical psychedelic drugs such as the tryptamine psilocybin can alter temporal perception. Previously, the phenylethylamine psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5-HT

objectivesAlthough DOI alters TDT performance, it is unclear whether timing is altered by tryptamine psychedelics, which are less selective for 5-HT

methodsTo address this knowledge gap, we tested psilocin (the active metabolite of psilocybin) in male C57BL/6J mice performing the TDT and assessed the involvement of 5-HT

resultsPsilocin (0.8 mg/kg SC) altered timing accuracy and precision in mice performing the TDT, similarly to DOI. Psilocin effects were blocked by the 5-HT

conclusionsThe mPFC appears to play a role in TDT performance and may mediate the effects of psychedelic drugs on interval timing.

Indexed as

5-HT2AHallucinogenMicePrefrontalPsilocinPsilocybinPsychedelicTiming

Identifiers

PMID42894023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.