In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Raymond Poon *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA.ORCID 0009-0009-8620-8235 Nidhi Satishkumar *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA.ORCID 0000-0003-1290-1159 Wesley A Mosimann *Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-2580-1042 Vedangi D HayatnagarkarDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA.ORCID 0009-0000-0516-9321 Swagata BoseDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA.ORCID 0000-0002-8655-7867 Vijay HemmadiDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA.ORCID 0000-0002-8169-6817 Skyler KuhnIntegrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0606-2125 Aditi ChatterjeeDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA.
Liam WorrallDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
Nathan P ManesFunctional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6701-3314 J Andrew N AlexanderDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-8759-1389 Justin LackIntegrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Henry F ChambersDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, CA, USA.ORCID 0000-0001-5317-4491 Aleksandra Nita-LazarFunctional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8523-605X Natalie C J StrynadkaDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
Som S ChatterjeeDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, USA. schatterjee@umaryland.edu.ORCID 0000-0002-7138-4449 Funding
Serine/threonine kinase signaling in beta-lactam resistance of Staphylococcus aureusR01AI165510 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Som Chatterjee · 2023 to 2026
$2.8MNIAID NIH HHS R01 AI165510U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI165510
6 · The paper itselfAbstract
Sensory induction of mecA expression plays a pivotal role in mediating broad-spectrum β-lactam resistance of MRSA. In contemporary MRSA isolates, sensory induction of β-lactam resistance originates at the membrane-associated BlaR1, which, upon detection of β-lactam drugs, triggers a signal transduction cascade that promotes mecA induction. We hereby show that phosphorylation of BlaR1, mediated through the serine-threonine kinase, Stk1, stabilizes its membrane-spanning state and retention, allowing for proper drug sensing and subsequent signal transduction events to occur, culminating in mecA-mediated β-lactam resistance. Our results demonstrate that targeting Stk1 can potentiate synthetic lethality to β-lactams in the majority of naturally isolated strains of MRSA. We additionally present the structural and kinetic basis for a Stk1-inhibitor complex that can enable rational design of Stk1-directed anti-MRSA therapeutics in the future. Our results reveal a novel role of the STK signaling pathway in bacterial protein stabilization in the cytosolic membrane.
Indexed as
Bacterial Proteinsbeta-Lactamasesbeta-Lactam ResistanceMethicillin-Resistant Staphylococcus aureusProtein Serine-Threonine KinasesStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial Agentsbeta Lactam Antibioticsbeta-LactamsMicrobial Sensitivity TestsPhosphorylationSignal TransductionVirulence FactorsAnti-Bacterial AgentsBacterial Proteinsbeta Lactam Antibioticsbeta-Lactamasesbeta-LactamsProtein Serine-Threonine KinasesStk1 protein, Staphylococcus aureusVirulence Factors
Identifiers
PMID42894009
PMCPMC13677706
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