Evidence map›Paper›PMID 42893993›Full record

ArticleNature communications2026

Insight into phase-sensitive optical coherence tomography displacement measurement.

Andrea Mazzolani, Jiayue Li, Balázs Dura-Kovács, Brendan F Kennedy, Peter R T Munro

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea MazzolaniDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK. andrea.mazzolani.18@ucl.ac.uk.ORCID http://orcid.org/0000-0003-3562-5281
Jiayue LiBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA, Australia.
Balázs Dura-KovácsDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID http://orcid.org/0009-0003-3939-0384
Brendan F KennedyBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA, Australia.
Peter R T MunroDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID http://orcid.org/0000-0001-9306-3673

Funding

Royal Society UF130304, URF 191036
6 · The paper itself

Abstract

Phase-sensitive optical coherence tomography (OCT) measures motion from phase differences between repeated acquisitions, supporting techniques such as Doppler OCT and optical coherence elastography (OCE). A recent numerical and experimental study showed that, even without noise, displacement estimation is less accurate in dark speckles. Here, we demonstrate analytically why displacement is not proportional to phase difference in speckled OCT images. We derive an expansion for compression OCE containing higher-order terms beyond the conventional linear term and show that neglecting them introduces errors that increase with depth and strain-discontinuity magnitude. We also identify two phenomena that perturb the phase linearity, one producing features resembling phase-wrapping events that may be mitigated by phase-unwrapping techniques. Finally, we introduce a displacement-estimation method that overcomes these limitations and achieves errors two orders of magnitude lower than conventional approaches. These phase-instability findings may reshape motion measurement beyond compression OCE, including dynamic OCT.

Identifiers

PMID42893993
PMCPMC13677722

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.