SynthesisNutrition & diabetes2026
Effectiveness of eHealth lifestyle interventions on management of metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.
Synthesis in Nutrition & diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
eHealth lifestyle interventions have emerged as promising management strategies for metabolic dysfunction-associated steatotic liver disease (MASLD). Our review aimed to synthesize the most recent evidence to evaluate the effectiveness of eHealth lifestyle interventions on clinical and behavioral outcomes in adults with MASLD. Twelve databases (Medline, Web of Science Core Collection, Embase, Cochrane Central Register of Controlled Trials, ProQuest Health & Medical Collection, CINAHL Complete, Academic Search Complete, Scopus, Emerald, China National Knowledge Infrastructure, Wanfang Data, and VIP Database) were searched from inception to April 2, 2025. Thirteen randomized controlled trials and fifteen quasi-experimental trials comprising 2579 adult patients with MASLD were included. Seven intervention components were identified: goal setting, health education, consultation, self- and device-monitoring, feedback, patient reminders, and social support. Meta-analysis of randomized controlled trials demonstrated that eHealth lifestyle interventions were significantly superior to standard care in reducing weight, body mass index, waist circumference, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transferase levels, and improving MASLD status. Improvements in self-management, dietary adherence, physical activity, exercise, and quality of life were also observed. Our findings suggest that ehealth intervention is a better choice for the patients with MASLD to achieve precise and scalable management. PROSPERO CRD420251001470.
trial registrationPROSPERO CRD420251001470; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251001470 .
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