Evidence map›Paper›PMID 42893976›Full record

ArticleNature communications2026

Practical synthesis of 3-Oxa/Aza-bicyclo[3.1.1]heptanes from 3-Oxa/Aza[3.1.1]propellanes.

Qin Jiang, Jianyang Dong, Fang Lei, Yanfeng Han, Mingxin Li, Yilin Zhang, Juan Fan, Huaming Sun, Ting Li, Shuoyi Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qin JiangKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Jianyang DongKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China. jydong@snnu.edu.cn.ORCID http://orcid.org/0000-0002-7070-0251
Fang LeiKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Yanfeng HanKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Mingxin LiKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Yilin ZhangKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Juan FanKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Huaming SunKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.ORCID http://orcid.org/0000-0001-7133-1948
Ting LiKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Shuoyi ChenKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Zhendan ChenKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China.
Dong XueKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China. xuedong_welcome@snnu.edu.cn.ORCID http://orcid.org/0000-0002-7269-6356

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22401177
6 · The paper itself

Abstract

While bicyclo[1.1.1]pentanes (BCPs) and bicyclo[3.1.1]heptanes (BCHeps) serve as established 3D bioisosteres for para- and meta-substituted benzenes, accessible via ring-opening of their corresponding propellanes, the integration of heteroatoms into these propellane scaffolds has remained elusive. Herein, we report the practical synthesis of 3-oxa/aza[3.1.1]propellanes, two heteroatom-containing analogues of propellane, from 1,5-diiodo-3-hetero-BCHeps. On this basis, radical-based transformations of 3-oxa/aza[3.1.1]propellane are established, enabling efficient and divergent access to a broad range of bridgehead-disubstituted 3-oxa/aza-BCHep derivatives as saturated isosteres of meta-substituted benzenes. Furthermore, representative 3-oxa-BCHep derivatives are converted into functionalized synthetic building blocks; this scaffold is also introduced into the antiepileptic drug URB597 and anticancer drug sonidegib. These results demonstrate that the 3-oxa/aza[3.1.1] frameworks provide a general and feasible synthetic platform for the construction of heteroatom-containing cage-like bioisosteres and the optimization of drug properties.

Identifiers

PMID42893976
PMCPMC13677720

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