Evidence map›Paper›PMID 42893795›Full record

ArticleBone & joint open2026

RESULT-Hip. The impact of restrictive compared with liberal transfusion strategy on cardiac injury and death in patients undergoing surgery for hip fracture : protocol for a multicentre, randomized controlled trial of two blood transfusion strategies.

RESULT Hip Study Group, Rhona C F Sinclair, Gayle Beveridge, Andrew D Duckworth, Annabel Giddings, Stephanie Cholbi, George V Guy, Sophie Birch, David A Hope, Joanne Singleton and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone & joint open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

RESULT Hip Study Group
Rhona C F SinclairRoyal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.
Gayle BeveridgeEdinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.
Andrew D DuckworthRoyal Infirmary of Edinburgh, Edinburgh, UK.
Annabel GiddingsEdinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.
Stephanie CholbiEdinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.
George V GuyICU Steps, London, UK.
Sophie BirchRoyal Infirmary of Edinburgh, Edinburgh, UK.
David A HopeRoyal Infirmary of Edinburgh, Edinburgh, UK.
Joanne SingletonRoyal Infirmary of Edinburgh, Edinburgh, UK.
Lucy MacdonaldRoyal Infirmary of Edinburgh, Edinburgh, UK.
Catriona KeerieEdinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.
Julia BoydEdinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.
Alixe H M KilgourRoyal Infirmary of Edinburgh, Edinburgh, UK.
Alasdair MacLullichRoyal Infirmary of Edinburgh, Edinburgh, UK.
Annemarie B DochertyRoyal Infirmary of Edinburgh, Edinburgh, UK.
Carol PorteousQueen Mary University of London, London, UK.
Matthew L CostaOxford Trauma and Emergency Care, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Nicholas L MillsRoyal Infirmary of Edinburgh, Edinburgh, UK.
Iain K MoppettAnaesthesia, Injury, Recovery and Inflammation Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
Rupert M PearseQueen Mary University of London, London, UK.
Simon J StanworthNHS Blood and Transplant and Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Andrew StoddartEdinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.
Steff LewisEdinburgh Clinical Trials Unit, The University of Edinburgh, Edinburgh, UK.
Timothy S WalshRoyal Infirmary of Edinburgh, Edinburgh, UK.
Michael A GilliesRoyal Infirmary of Edinburgh, Edinburgh, UK.

Funding

National Institute for Health and Care ResearchWellcome Trust
6 · The paper itself

Abstract

Aims: Hip fracture is a global health issue. Complications are common, leading to reduced quality of life or death. These occur more frequently if anaemia is present. We hypothesize that correcting anaemia in the perioperative period may decrease major adverse cardiac events (MACE) and death after hip fracture. Methods: This multicentre prospective randomized trial compares transfusion strategies after hip fracture in patients aged ≥ 60 years. We initially planned to randomize 1,984 participants with anaemia, defined as haemoglobin ≤ 90 g l Results: This trial was funded by the National Institute for Health and Care Research, HTA award (National Institute for Health and Care Research (NIHR) 130875) and registered at ISRCTN 28818784. Ethical approval was obtained to recruit patients in the UK. As recruitment fell short of the initial target, and following consultation with the funder, we refined our primary outcome to include myocardial injury after non-cardiac surgery (MINS), and reduced the required sample size to 842. Conclusion: Recruitment commenced on 10 June 2022. The first participant was recruited on 16 June 2022. We will engage clinicians and healthcare planners to implement the findings. We plan to recruit until 31 October 2026. Results will be disseminated to clinicians, policymakers, patients, and the public.

Identifiers

PMID42893795
PMCPMC13677165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.