ArticleAnimal genetics2026
A Nelore Cattle Structural Variant Catalog.
Article in Animal genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Structural variants (SVs) contribute more nucleotide divergence between mammalian genomes than single nucleotide polymorphisms, yet no population-scale, long-read-validated SV catalog has been available for Bos indicus cattle. Nelore, the most numerically important indicine breed worldwide, diverges substantially from the taurine-derived reference genome used for most bovine SV discovery, leaving its structural variation largely uncharacterized. Long-read sequencing of 20 Nelore bulls with two complementary callers (Sniffles2, SVIM) yielded 82 581 dual-caller concordant SVs, of which 74 222 insertions and deletions passed independent read-based validation. Ensembl VEP annotation identified 561 HIGH-impact variants (0.75% of the catalog) across 7040 protein-coding genes. Only 22 894 SVs (30.7%), including 147 of 561 HIGH-impact variants (26.2%), could be tagged by an existing BovineHD SNP (r
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