Evidence map›Paper›PMID 42893502›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Acinar-Derived Organoids Reveal Stage-Specific Control of Acinar Plasticity.

Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongfei Hou *Institute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0009-1332-3064
Siyu Li *Institute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Chunying Li *Institute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Zhifan LinInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Dan HeInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Li YangInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Liping FuInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Qianyue ZhangInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Tianping ZhouDepartment of Orthopedics, Zhabei Central Hospital Affiliated to Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-5834-1604
Yao YaoInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xiaolei YinInstitute for Regenerative Medicine, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0001-8624-8928

Funding

Fundamental Research Funds for the Central Universities 22120250374National Key R&D Program of China 2020YFA0112500National Key R&D Program of China 2025YFA1804200National Natural Science Foundation of China 31970820National Natural Science Foundation of China 32500636National Natural Science Foundation of China 32500638National Natural Science Foundation of China 32595480Peak Disciplines (Type IV) of Institutions of Higher Learning in ShanghaiTongji University Medicine-X Interdisciplinary Research Initiative 2026-YB-0255C-06
6 · The paper itself

Abstract

Adult pancreatic acinar cells undergo ordered metaplastic conversion during injury and tumor initiation. Whether individual cells retain redifferentiation capacity after metaplastic expansion, and what signals each transition requires, remains unknown. Here, using organoids derived from single acinar cells, we show that expanded acinar-lineage organoids can reacquire acinar features under stage-specific culture conditions. We defined conditions that preserve acinar identity ex vivo and showed that epidermal growth factor (EGF)/EGF receptor (EGFR) signaling initiates conversion from this maintained state. The expansion trajectory recapitulates injury- and oncogene-associated acinar-to-ductal metaplasia (ADM) programs in vivo. After expansion, the conditions that preserved acinar identity could not restore it; a staged regimen containing transient insulin-like growth factor 1 receptor (IGF1R) inhibition and dexamethasone promoted redifferentiation. The Kras

Indexed as

acinar‐to‐ductal metaplasiacell plasticityoncogenic Krasorganoidsredifferentiation

Identifiers

PMID42893502
PMCPMC13677045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.