ArticleOncoTargets and therapy2026
High Density of Cancer-Associated Fibroblasts Correlates with Increased Lymphangiogenesis and Poor Prognosis in Hypopharyngeal Carcinoma.
Article in OncoTargets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to investigate the relationship between Cancer-associated fibroblasts (CAFs), microlymphatic vessel density (MLVD), clinicopathological factors, and survival outcomes in HPSCC patients. Methods: Clinical data were collected from patients diagnosed with HPSCC in the Department of Otolaryngology and Head and Neck Surgery at the 980th Hospital of PLA Joint Logistics Support Force (Bethune International Peace Hospital) from January 1, 2010, to October 1, 2022. CAFs, MLVD, and related factors were analyzed. Results: CAF numbers and MLVD were relatively high in tumor tissues, positively correlated with each other, and linked to clinicopathological factors and poor survival. N stage, number of CAFs, and MLVD affected prognosis, with N stage and MLVD identified as independent risk factors. Conclusions and Significance: The correlation between CAF density and MLVD suggests a potential association between CAFs and lymphangiogenesis in HPSCC. MLVD may serve as a prognostic biomarker, and CAF-associated lymphangiogenesis warrants further investigation.
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