ArticleAmerican journal of ophthalmology case reports2026
Ocular morbidity in uveal melanocytoma associated with MEN1 syndrome.
Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To report an aggressive case of melanocytoma with evidence of malignant melanoma transformation in a young patient with MEN1 syndrome. Observations: A 24-year-old female with known MEN1 syndrome presented with new onset floaters in the right eye. Posterior examination demonstrated a pigmented mass. Initial biopsy demonstrated evidence of melanocytoma. Within 4 months, the patient returned with remarkable tumor growth, significantly decreased vision, and pain. Enucleation ensued and pathology revealed ciliary body melanocytoma with evidence of early malignant transformation to melanoma. A somatic gene panel for uveal melanoma was negative, however next generation sequencing demonstrated a variant in Conclusions and importance: This case demonstrates a rare and rapid progression of uveal melanocytoma in the setting of MEN1. While suspected genetic analysis of key uveal melanoma genes remained negative, final biopsy yielded a transforming melanocytoma with an
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