ArticleAmerican journal of preventive cardiology2027
Pro-inflammatory cytokines moderated by visceral adiposity from a pragmatic randomized crossover trial of portable HEPA air purifiers.
Article in American journal of preventive cardiology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Airborne particulate matter (PM) increases the risk of cardiovascular disease. High efficiency particulate arrestance (HEPA) filtration can reduce indoor PM, but evidence is lacking as to whether HEPA filtration has an effect on pro-inflammatory cytokines. Methods: This pragmatic crossover trial randomly assigned participants to 30 days of HEPA or sham filtration, followed by a 30-day washout, and then 30 days of the alternative. Concentrations of interleukin-1β (IL-1β), interleukin 6 (IL-6), and high-sensitivity C-reactive protein (hsCRP) were measured in quality-controlled peripheral blood plasma samples using ultra-sensitive assays. Linear mixed models compared HEPA to sham filtration. The moderating effect of visceral adipose tissue (VAT) was assessed using a dichotomized A Body Shape Index (ABSI) z-score and other measures of adiposity. Results: Among 116 participants, mean age was 41.5 years, 58.6% were female, and 72.4% were non-Hispanic White. No overall difference in mean IL-1β concentration was observed between HEPA and sham filtration. However, VAT significantly moderated the results (test for interaction Conclusions: VAT moderated inflammatory responses to HEPA filtration, with a significant reduction in IL-1β among participants with excessive VAT.
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