ArticleAmerican journal of preventive cardiology2027
Genetically determined very low lipoprotein(a) is not associated with type 2 diabetes and glycemic traits.
Article in American journal of preventive cardiology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Background: Lipoprotein (a) [Lp(a)] is an independent atherosclerotic cardiovascular disease risk factor, with levels largely determined by variation in the Objectives: Estimate associations between very low Lp(a), inferred by Methods: A multi-population study of European, Hispanic/Latino, and South Asian populations from five cohort studies was assembled. Effects of the null allele rs41272114 (CC, wild-type; T, null allele) on type 2 diabetes and glycemic biomarkers (fasting glucose, fasting insulin, glycosylated hemoglobin (HbA1c), triglyceride-to-high-density lipoprotein ratio, and HOMA-IR) were estimated using multivariable-adjusted and cohort-specific linear or logistic regression models that were combined using inverse variance meta-analysis. Results: Of n=519,892 participants, the T null allele was common (n=49,841 CT and n=2,039 TT) and n=38,320 participants had type 2 diabetes (prevalence range: 4.7, 29.5%). Participants with the TT genotype had a median Lp(a) ranging 1.5-1.9 nmol/L compared to median Lp(a) ranging 15.8-30.0 nmol/L in participants with the CC genotype. We did not observe increased odds of type 2 diabetes by rs412722114 genotype (OR Conclusions: In a large multi-population study with high burdens of type 2 diabetes, life-long very low Lp(a) did not increase type 2 diabetes risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.