ArticleInternational journal of chronic obstructive pulmonary disease2026
Association of Low Weight-Adjusted Muscle Mass with the Frequent Exacerbation Phenotype in COPD: A Retrospective Cross-Sectional Study.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Traditional height-adjusted muscle mass index (ASMI) may be influenced by weight loss in advanced COPD. This study compared the associations of ASMI and appendicular skeletal muscle mass-to-body mass index ratio (ASM/BMI) with the frequent exacerbation phenotype, assessed whether the ASM/BMI association differed by BMI category, and evaluated the discriminative performance of ASM/BMI. Patients and Methods: This retrospective cross-sectional study included 419 patients with COPD. Body composition was measured using multifrequency bioelectrical impedance analysis. Multivariable logistic regression and subgroup interaction analyses were used to evaluate the independent associations of ASMI and ASM/BMI with the frequent exacerbation phenotype (≥2 moderate or ≥1 severe exacerbations in the preceding year). Results: Low ASMI was not significantly associated with the frequent exacerbation phenotype (adjusted OR [aOR], 1.52; 95% CI, 0.96-2.41). Low ASM/BMI was significantly associated with this phenotype (aOR, 1.74; 95% CI, 1.07-2.87). This association was modified by BMI (P Conclusion: In COPD, muscle mass should be interpreted in the context of body weight. Low ASM/BMI was strongly associated with the frequent exacerbation phenotype specifically among patients with a BMI < 24 kg/m
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