Evidence map›Paper›PMID 42893061›Full record

ArticleAmerican journal of preventive cardiology2027

Whole heart atherosclerosis volume and risk for major adverse cardiovascular events across the clinical likelihood for obstructive CAD; the CONFIRM2 study.

Alexander van Rosendael, Rine Nakanishi, Jeroen J Bax, Gianluca Pontone, Saima Mushtaq, Ronny R Buechel, Christoph Gräni, Gudrun Feuchtner, Pietro G Lacaita, Amit R Patel and 47 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Alexander van RosendaelDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Rine NakanishiDepartment of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Gianluca PontoneDepartment of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.
Saima MushtaqPerioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, Milan, Italy.
Ronny R BuechelDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Christoph GräniDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Gudrun FeuchtnerDepartment of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
Pietro G LacaitaDepartment of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
Amit R PatelDivision of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, USA.
Cristiane C SingulaneDivision of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, USA.
Andrew D ChoiDepartment of Cardiology and Radiology, George Washington University, Washington, District of Columbia, USA.
Mouaz Al-MallahDepartment of Cardiology, Houston Methodist, Houston, TX, USA.
Daniele AndreiniDivision of University Cardiology, IRCCS Galeazzi Sant'Ambrogio, Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Ronald P KarlsbergCardiovascular Research Foundation of Southern California, Beverly Hills, CA, USA.
Geoffrey ChoCardiovascular Research Foundation of Southern California, Beverly Hills, CA, USA.
Carlos E RochitteHeart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Mirvat AlasnagCardiac Center, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
Ashraf HamdanDepartment of Cardiology, Rabin Medical Center, Petah Tikva & Tel-Aviv University, Tel-Aviv, Israel.
Filippo CademartiriIstituto di Ricovero e Cura a Carattere Scientifico SYNLAB Servizi Diagnostici Nucleari, Naples, Italy.
Erica MaffeiDepartment of Radiology, Istituto di Ricerca e Cura a Carattere Scientifico SYNLAB SDN, Naples, Italy.
Hugo MarquesUNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Imaging Department, Católica Medical School, Lisbon, Portugal.
Pedro M Gonçalves PereiraUNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Imaging Department, Católica Medical School, Lisbon, Portugal.
Himanshu GuptaCardiac Imaging, Heart and Vascular Institute, Valley Health System, Paramus, NJ, USA.
Martin HadamitzkyDepartment of Cardiovascular Radiology and Nuclear Medicine, TUM University Hospital German Heart Center, Munich, Germany.
Omar KhaliqueDivision of Cardiovascular Imaging, St. Francis Hospital and Heart Center, Roslyn, NY, USA.
Dinesh KalraDivision of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
James D MillsDepartment of Medicine, Division of Cardiovascular Diseases & Hypertension, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
Nick S NurmohamedDepartment of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Paul KnaapenDepartment of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Matthew BudoffThe Lundquist Institute, Torrance, CA, USA.
Kashif ShaikhUniversity of Tennessee Medical Center, Knoxville, TN, USA.
Enrico MartinDivision of Cardiology, MercyOne-Iowa Heart Center, Des Moines, IA, USA.
David M GermanKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
Maros FerencikKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
Andrew C OehlerAllegheny Health Network Cardiovascular Institute, Allegheny Health Network, Pittsburgh, PA, USA.
Roderick DeañoDepartment of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Prashant NagpalDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Marly van AssenDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Carlo Nicola De CeccoDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Vasileios Kamperidis1st Cardiology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Borek FoldynaDepartment of Radiology, Cardiovascular Imaging and Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jan Michael BrendelDepartment of Radiology, Cardiovascular Imaging and Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Victor Y ChengMinneapolis Heart Institute, Minneapolis, MN, USA.
Kelley BranchDivision of Cardiology, University of Washington, Seattle, WA, USA.
Marcio BittencourtHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Sabha BhattiNational Institute of Cardiovascular Diseases, Karachi, Pakistan.
Venkateshwar PolsaniPiedmont Heart Institute, Atlanta, GA, USA.
George WesbeyDepartment of Cardiovascular Computed Tomography, Scripps Clinic, La Jolla, CA, USA.
Rhanderson CardosoDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ron BlanksteinDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Augustin DelagoMedical Data Research Collaborative, London, United Kingdom.
Amit PursnaniCardiology, Endeavor NorthShore Cardiovascular Institute, Evanston, IL, USA.
Amro AlsaidDepartment of Cardiac Imaging, Baylor Scott and White, The Heart Hospital Plano, Plano, TX, USA.
Vasvi SinghMidwest Heart & Vascular Associates, Kansas City, MO, USA.
Melissa AquinoCleerly, Inc, Denver, CO, USA.
Ibrahim DanadDepartment of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The totality of atherosclerosis from the coronary tree can be measured with quantitative coronary CT and is increasingly being recognized as important marker for future cardiovascular events. We evaluated the risk and absolute event rates of plaque volume staging systems and provided analyses according to the clinical likelihood of obstructive CAD. Methods: CONFIRM2 is an ongoing, global, multicenter, observational registry that included patients with clinically indicated coronary CT angiography and follow-up for major adverse cardiovascular events (MACE). Patients without cardiac symptoms and prior CAD were excluded. Atherosclerosis was quantified across all coronary segments by AI-QCT. Total plaque volume (TPV) was categorized into non-calcified plaque (NCPV, HU <350) and calcified (HU>350). The primary end point was the incidence rate of MACE over at 4 years and included all-cause mortality, myocardial infarction, stroke, congestive heart failure, late revascularizations (occurring >90 days post index CCTA), and hospitalization for unstable angina. Secondary endpoint included Death, MI, and stroke. The prognostic value of TPV and NCPV was evaluated across the pretest likelihood according to the ESC Risk Factor Weighted Likelihood (ESC RF-CL). Results: A total of 6061 patients (mean age 58.6 ± 12.1 years, 48.6% male) were included and the mean follow-up duration was: 4.4 ± 1.8 years. According to the ESC RF-CL for obstructive CAD, patients were classified as very-low, low, and moderate risk in 36.0%, 43.0%, and 22.0%, and obstructive CAD rates were 6.8%, 15.7%. and 28.2, respectively. Within the total cohort, TPV >0-250, 250-750, and >750 mm Conclusion: Among a large cohort of symptomatic patients evaluated by coronary CT angiography, the burden of atherosclerosis by AI-QCT was the main driver for cardiovascular events. Absolute event rates were consistently higher by each plaque volume stage, and consistent across the clinical likelihood subgroups for obstructive CAD. While quantitative atherosclerosis was present in the majority of patients, risk increased significantly from 250 mm

Indexed as

AICoronary plaqueRisk stratification

Identifiers

PMID42893061
PMCPMC13676140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.