ArticleAmerican journal of preventive cardiology2027
Association of reproductive factors with acute myocardial infarction in young women: A VIRGO and NHANES case-control study.
Article in American journal of preventive cardiology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Objective: Young women with acute myocardial infarction (AMI) often present with distinct risk profiles compared with older women and men, but the role of reproductive factors remains poorly understood. This study examines associations of reproductive factors with AMI in young women. Methods: We conducted a case-control study of 1561 women aged 18-55 years with AMI from VIRGO and age-matched controls from NHANES. A wide range of reproductive factors were evaluated. Conditional logistic regression estimated odds ratios for AMI, sequentially adjusted for race/ethnicity, socioeconomic variables, and traditional risk factors. Stratified analyses were performed by menopausal status. Results: Early menarche (<11 years; OR 2.07, 95% CI 1.56-2.73), menopause (OR 1.82, 95% CI 1.50-2.22), gestational diabetes (OR 1.65, 95% CI 1.23-2.19), birth control pills use for 1-5 years (OR 1.67, 95% CI 1.36-2.05), and ever use of female hormones (OR 1.99, 95% CI 1.62-2.46) were associated with higher odds of AMI, while first live birth at ≥30 years (OR 0.50, 95% CI 0.36-0.69), breastfeeding ≥1 month (OR 0.46, 95% CI 0.38-0.56), and current contraceptive use (OR 0.49, 95% CI 0.32-0.76) were associated with lower odds. After adjustment for traditional risk factors, birth control pills use for 1-5 years (OR 1.71, 95% CI 1.25-2.34) and female hormone use (OR 1.75, 95% CI 1.28-2.38) remained significantly associated. Associations varied by menopausal status. Conclusion: Reproductive factors are associated with early-onset AMI in young women. Recognition of reproductive history may inform prevention strategies in young women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.