Orbital metastasis revealing occult metastatic prostate adenocarcinoma in a South African man: A rare initial ophthalmic presentation.

Greg Samuels, Yasmin Kahn, Mohammed Salah E Khalifa Salem, Alain Mwamba Mukendi

Abstract readCase Reports

In one paragraph

Article in Urology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Greg SamuelsChris Hani Baragwanath Academic Hospital, Division of Urology, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, South Africa.

Yasmin KahnChris Hani Baragwanath Academic Hospital, Division of Ophthalmology, Department of Neurosciences, Faculty of Health Sciences, University of the Witwatersrand, South Africa.

Mohammed Salah E Khalifa SalemKlerksdorp/Tshepong Hospital Complex, Division of Urology, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, South Africa.

Alain Mwamba MukendiCharlotte Maxeke Johannesburg Academic Hospital, Division of Urology, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orbital metastasis is a rare initial presentation of undiagnosed prostate cancer. We report a 65-year-old South African man presenting with a one-year history of progressive, painless right upper eyelid swelling, proptosis, tearing, and vision loss. Imaging revealed a right lateral orbital mass causing bone erosion. An incisional biopsy confirmed metastatic adenocarcinoma with strong prostate-specific antigen positivity. Further evaluation showed an irregular prostate, a serum PSA of 1620 ng/mL, urinary retention, nodal involvement, and extensive bone metastases. A prostate biopsy confirmed high-grade disease (Gleason 9). This case underscores considering a prostatic primary in older men with suspicious orbital masses.

Indexed as

Orbital metastasisProptosisProstate cancerProstate-specific antigen

Identifiers

PMID42893042

DOI10.1016/j.eucr.2026.103640

PMCPMC13675850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.