ArticleInternational journal of cardiology. Heart & vasculature2026
The impact of residual vessel fractional flow reserve on clinical outcomes: The FAST residual study.
Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Backgrounds: Vessel fractional flow reserve (vFFR) allows angiography-based physiological lesion evaluation and virtual percutaneous coronary intervention (PCI) simulation, estimating post-PCI vFFR (residual vFFR). While residual vFFR has been validated against invasive post-PCI fractional flow reserve (FFR), its clinical significance remains unclear. To assess the impact of residual vFFR on long-term clinical outcomes. Methods: FAST Residual is a post hoc analysis of the FFR SEARCH study including 279 patients with (un)stable angina or non-ST-segment elevation myocardial infarction undergoing angiographically successful PCI. Residual vFFR was calculated based on two pre-procedural angiographic views. The primary endpoint was target vessel failure (TVF) at 5 years, a composite of cardiac death, target vessel myocardial infarction (TVMI) and target vessel revascularization (TVR). Results: Mean age was 64 ± 11 years, 68.5% were men, 23.7% had diabetes, and 43.7% presented with stable angina. Median residual vFFR was 0.92 [IQR 0.87-0.95] and post-PCI FFR was 0.90 [0.85-0.94] ( Conclusions: The concept of virtual stenting is a promising tool for predicting clinical outcomes. For the first time, this post hoc analysis showed that patients with residual vFFR <0.90 experienced significantly higher rates of TVF at 5 years.
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