Evidence map›Paper›PMID 42893021›Full record

ArticleBiological psychiatry global open science2026

Selective mGlu

Deborah J Luessen, Isabel M Gallinger, Brenna Wolfe, Mac J Meadows, Michael Z Leonard, Geanne A Freitas, Craig W Lindsley, Erin S Calipari, Colleen M Niswender, P Jeffrey Conn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deborah J LuessenDepartment of Pediatrics, Emory University, Atlanta, Georgia.
Isabel M GallingerDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Brenna WolfeDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Mac J MeadowsDepartment of Pediatrics, Emory University, Atlanta, Georgia.
Michael Z LeonardDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Geanne A FreitasDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Erin S CalipariDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Colleen M NiswenderDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.
P Jeffrey ConnDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee.

Funding

REGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9M
Program in NeurogenomicsT32MH065215 · NIMH · VANDERBILT UNIVERSITY · PI ROGER J COLBRAN · 2002 to 2026
$6.4M
FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPESR01NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 1993 to 2025
$6.2M
Discovery of mGlu receptor PAMs for treatment of schizophreniaR01MH119673 · NIMH · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2019 to 2023
$3.6M
Functions of Metabotropic Glutamate Receptor SubtypesR37NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2014 to 2020
$3.5M
NIMH NIH HHS R01 MH062646NIMH NIH HHS R01 MH119673NIMH NIH HHS T32 MH065215NINDS NIH HHS R01 NS031373NINDS NIH HHS R37 NS031373
6 · The paper itself

Abstract

Background: Deficits in prefrontal cortex (PFC) inhibitory transmission are thought to underlie the cognitive symptoms of schizophrenia that remain untreated by current pharmacotherapies. The metabotropic glutamate 1 (mGlu Methods: We used a subchronic phencyclidine (PCP) NMDA receptor antagonist mouse model, mGlu Results: Subchronic PCP treatment impaired inhibitory synaptic transmission in the PFC, particularly onto layer V pyramidal neurons projecting to the nucleus accumbens. Pharmacological activation of mGlu Conclusions: These findings identify SST-IN-expressed mGlu

Indexed as

CognitionElectrophysiologyExcitation-inhibition balanceNeuropharmacologySchizophrenia

Identifiers

PMID42893021
PMCPMC13676117

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.