Evidence map›Paper›PMID 42893007›Full record

ArticleMilitary Medical Research2026

Blockade of EP3 attenuates cardiac fibrosis by suppressing TGF-β1-Smad2/3 signaling through the Smurf2-mediated Smad7 ubiquitination.

Lan Ye, Hu Xu, Hui Tang, Qing-Wei Li, Xiu-Hui Mao, Er-Jiao Qiang, Jia-Yao Zhang, Bo Liang, Li-Hong Chen, You-Fei Guan and 1 more

Abstract read
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In one paragraph

Article in Military Medical Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lan YeAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, Liaoning, China.
Hu XuHealth Science Center, East China Normal University, Shanghai 200241, China.
Hui TangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, Liaoning, China.
Qing-Wei LiAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, Liaoning, China.
Xiu-Hui MaoHealth Science Center, East China Normal University, Shanghai 200241, China.
Er-Jiao QiangDepartment of Pathology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.
Jia-Yao ZhangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, Liaoning, China.
Bo LiangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, Liaoning, China.
Li-Hong ChenHealth Science Center, East China Normal University, Shanghai 200241, China.
You-Fei GuanAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, Liaoning, China.
Xiao-Yan ZhangHealth Science Center, East China Normal University, Shanghai 200241, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sustained β-adrenergic activation induces cardiac fibrosis, which is characterized by excessive deposition of extracellular matrix (ECM) secreted by activated cardiac fibroblasts (CFs). Prostaglandin E Methods: To elucidate the role of EP3 in cardiac fibrosis, the global Results: Echocardiography assay showed that both EP3 Conclusions: This study demonstrates that CF-EP3 contributes to β-adrenergic activation-induced cardiac fibrosis and target of EP3 represents a potential therapeutic strategy for the treatment of cardiac fibrosis.

Indexed as

FibrosisReceptors, Prostaglandin E, EP3 SubtypeAnimalsDinoprostoneIsoproterenolMaleMiceMice, KnockoutMyocardiumSignal TransductionSmad2 ProteinSmad3 ProteinSmad7 ProteinTransforming Growth Factor beta1UbiquitinationUbiquitin-Protein LigasesDinoprostoneIsoproterenolPtger3 protein, mouseReceptors, Prostaglandin E, EP3 SubtypeSmad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseSmad7 ProteinsulprostoneTransforming Growth Factor beta1Ubiquitin-Protein LigasesCardiac fibrosisE-type prostanoid receptor 3 (EP3)Smad7TGF-β signalingUbiquitination

Identifiers

PMID42893007
PMCPMC13676097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.