Evidence map›Paper›PMID 42892936›Full record

ArticleClinical and translational radiation oncology2027

Feasibility and potential benefits of daily online adaptive radiotherapy for head and neck cancer without margin reduction using an RTT-only workflow.

A M Lindegaard, K Håkansson, A Appelt, M Bernsdorf, A B Gothelf, T R B Jensen, A Mohammad, C A Kristensen, I Vogelius, J Friborg

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In one paragraph

Article in Clinical and translational radiation oncology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

A M LindegaardDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
K HåkanssonDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
A AppeltDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
M BernsdorfDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
A B GothelfDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
T R B JensenDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
A MohammadDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
C A KristensenDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
I VogeliusDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
J FriborgDepartment of Oncology, Centre for Cancer and Organ diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Online adaptive radiotherapy (oART) may improve head and neck cancer (HNC) treatment, where anatomical changes during radiotherapy (RT) are common. However, oART is resource-intensive and clinical data are limited. We conducted a prospective feasibility trial implementating an RT technologist (RTT)-led workflow to evaluate dosimetric outcomes, workflow strategies, and intrafractional motion in daily oART. Material and methods: Ten patients receiving curatively intended oART (33-34 fractions) using standard PTV margins were included (NCT: 07506902). For each fraction, a scheduled plan (original plan recalculated on daily anatomy) and an adapted plan (reoptimized to daily anatomy) were generated, and the preferred plan was delivered. Target coverage (PTV1 V95%), mean dose (D Results: A total of 322 adaptive session were completed. The median treatment time was 29.9 min. The adapted plan was selected in 78% of fractions. oART improved target coverage in 76% of fractions. D Conclusion: Daily oART for HNC is feasible with improvements in target coverage but modest and inconsistent OAR sparing.

Indexed as

Adaptive radiotherapyDaily online adaptive radiotherapyHead and neck cancerOnline adaptive radiotherapy

Identifiers

PMID42892936
PMCPMC13675470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.