Evidence map›Paper›PMID 42892892›Full record

ArticleiScience2026

A multimodal

Tobias Britzke, Jacob Schön, Nico Joël Halwe, Lorenz Ulrich, Jana Kochmann, Björn Corleis, Robert Klopfleisch, Martin Beer, Donata Hoffmann, Angele Breithaupt

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tobias BritzkeDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Jacob SchönInstitute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Nico Joël HalweInstitute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Lorenz UlrichInstitute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Jana KochmannInstitute of Immunology, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Björn CorleisInstitute of Immunology, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Robert KlopfleischInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
Martin BeerInstitute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Donata HoffmannInstitute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.
Angele BreithauptDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory viruses frequently initiate infection in the nasal mucosa, where virus-host interactions shape disease progression and transmission. Yet this site remains undercharacterized due to anatomical and technical challenges. Spatially resolved technologies are limited by cost and complexity, leaving most studies reliant on bulk or descriptive approaches lacking spatial context. We present a framework for spatially resolved investigation of infections in the nasal cavity. Using wild-type SARS-CoV-2 and two live-attenuated vaccines (OTS-206, OTS-228) as model viruses in Syrian hamsters, we integrate standardized sampling, histopathology, immunohistochemistry, multiplex RNA

Indexed as

histopathologyimmunohistochemistrylive-attenuated vaccinenasal mucosaquantitative image analysisrespiratory virus infectionRNA in situ hybridizationSARS-CoV-2spatial analysisvirus-host interactions

Identifiers

PMID42892892
PMCPMC13675480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.