ArticleParasite epidemiology and control2026
Diagnostic value of microscopic blood smear examination using a digital cell morphology system for human granulocytic anaplasmosis.
Article in Parasite epidemiology and control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Human granulocytic anaplasmosis (HGA) is an emerging tick-borne zoonosis caused by Methods: Between 2019 and 2025, for each HGA PCR request at the Colmar Civil Hospitals, two May-Grünwald Giemsa-stained BS were prepared, digitized, and the cells preclassified using the CellaVision® System systematically. Retrospectively, two microbiologists performed a review of the recorded images for all positive HGA PCR results to identify intragranulocyte morulae independently and blinded to each other's findings. Results: A total of 101 PCR tests for HGA were performed in 92 patients, with 5 patients testing positive (median time to results: 6 days). In all 5 patients, images of intragranulocyte morulae were obtained using the CellaVision® system, and the examination was completed in under 15 min. Conclusions: Using the CellaVision® system for BS analysis with a standardized review protocol simplifies the reading process. The method successfully detected morulae in all confirmed cases included in this preliminary study though prospective validation is still required. However, a negative digitally assessed blood smear must not be interpreted as excluding HGA.
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