Evidence map›Paper›PMID 42892663›Full record

ArticleAnnals of surgical oncology2026

Does Additional Margin Excision During Pegulicianine Fluorescence-Guided Surgery (pFGS) Affect Patient Breast Satisfaction?

Kyle J Anderman, Abigail E Daly, Nina Tamirisa, Kelly K Hunt, E Shelley Hwang, Irene L Wapnir, Peter W Blumencranz, David Carr, Logan R Holt, Kate Smith and 2 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kyle J Anderman *Massachusetts General Brigham, Boston, MA, USA.
Abigail E Daly *Massachusetts General Brigham, Boston, MA, USA.
Nina TamirisaMD Anderson Cancer Center, Houston, TX, USA.
Kelly K HuntMD Anderson Cancer Center, Houston, TX, USA.
E Shelley HwangDuke University Health System, Durham, NC, USA.
Irene L WapnirStanford University Medical Center, Stanford, CA, USA.
Peter W BlumencranzBayCare Medical Group, Clearwater, FL, USA.
David CarrNovant Health, Winston-Salem, NC, USA.
Logan R HoltMassachusetts General Brigham, Boston, MA, USA.
Kate SmithLumicell, Inc., Newton, MA, USA.
Jorge FerrerLumicell, Inc., Newton, MA, USA.
Barbara L SmithMassachusetts General Brigham, Boston, MA, USA. blsmith1@mgh.harvard.edu.

Funding

Division of Cancer Prevention, National Cancer Institute 1R01CA212138-0Division of Cancer Prevention, National Cancer Institute 1R44CA211013-01
6 · The paper itself

Abstract

backgroundUse of pegulicianine fluorescence-guided surgery (pFGS) for intraoperative residual tumor assessment in breast cancer lumpectomy surgery removed additional tumor and reduced second surgeries. This study assessed breast satisfaction among patients with and without additional margin excision and preference for optimizing cosmesis versus avoiding a second surgery.

methodsTwo clinical trials randomized stages 0 to 3 breast cancer patients to pFGS or standard lumpectomy. For pFGS, additional cavity margin specimens were taken at sites of pegulicianine fluorescence after standard lumpectomy. Surveys of BREAST-Q satisfaction were administered in trials 1 and 2, and surveys of cancer worry and patient preference information (PPI) were administered in trial 2.

resultsSatisfaction surveys were completed 6 to 12 months postoperatively by 14 % of the trial 1 and 67 % of the trial 2 patients. The mean postoperative breast satisfaction score was 75.8 (n = 99; range, 15-100) for the pegulicianine-assisted arm patients versus 79.0 (n = 19; range, 35-100) for the control subjects (p = 0.53). The mean breast satisfaction score was 73.6 (n = 52; range, 33-100) among the patients with additional pFGS-assisted cavity margins taken versus 78.5 (n = 66; range, 15-100) (p = 0.17) among those with no additional tissue taken. Overall, 70.6 % of the respondents strongly preferred or preferred avoiding a second surgery, 19.6 % had no preference, and only 9.8 % preferred to optimize cosmetic outcomes. No patient strongly preferred to optimize cosmetic outcomes

conclusionsNo decrease in breast satisfaction was observed among the breast cancer lumpectomy patients undergoing pFGS intraoperative margin assessment despite additional tissue removal. Most of the patients valued avoiding a second surgery over maximizing cosmetic outcome.

Indexed as

Breast cancerBreast conserving surgeryBreast satisfactionCosmetic outcomesIntraoperative margin assessmentPatient-reported outcomesPegulicianine fluorescence-guided surgeryRe-excision

Identifiers

PMID42892663

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