Evidence map›Paper›PMID 42892652›Full record

ArticleDiabetologia2026

Renal tubule-specific Nrf2 deletion ameliorates diabetic kidney disease by attenuating glomerular hypertension and kidney injury in a mouse model of diabetes.

Ke Su, Jing Zhou, Yuchao Pang, Shiao-Ying Chang, Min-Chun Liao, Wen-Xia Yang, Shuiling Zhao, Junzheng Peng, Daniel N Leal, Michifumi Yamashita and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ke SuCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.ORCID http://orcid.org/0000-0001-8134-7310
Jing ZhouCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.
Yuchao PangCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.
Shiao-Ying ChangCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.
Min-Chun LiaoCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.
Wen-Xia YangCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.
Shuiling ZhaoCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.
Junzheng PengCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada.
Daniel N LealDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Michifumi YamashitaDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6221-8900
Kana N MiyataDivision of Nephrology, Department of Internal Medicine, Saint Louis University, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-6486-4666
Janos G FilepCentre de Recherche, Hôpital Maisonneuve-Rosemont and Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, QC, Canada.ORCID http://orcid.org/0000-0001-5022-3534
Julie R IngelfingerPediatric Nephrology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9039-2703
Shao-Ling ZhangCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada. shao.ling.zhang@umontreal.ca.ORCID http://orcid.org/0000-0002-5255-6970
John S D ChanCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, QC, Canada. john.chan@umontreal.ca.ORCID http://orcid.org/0000-0002-7137-454X

Funding

Institute of Nutrition, Metabolism and Diabetes MOP-86450Institute of Nutrition, Metabolism and Diabetes MOP-97742Institute of Nutrition, Metabolism and Diabetes PJ9-179813/PJ9-184014/PJT-186199Kidney Foundation of Canada 856016-21KHRGKidney Foundation of Canada KHRG2023-1037528
6 · The paper itself

Abstract

aims/hypothesisWe previously reported that expression of nuclear factor erythroid 2-related factor 2 (NRF2) is upregulated in the renal tubules of humans with diabetes and in mouse models of diabetes. We hypothesised that Nrf2 deletion would ameliorate renal hyperfiltration and kidney injury in Akita mice (a model of type 1 diabetes).

methodsAkita Nrf2

resultsThe glomerular filtration rate (GFR), kidney hypertrophy, tubular injury score, glomerular basement membrane thickness, podocyte loss and foot process effacement and urinary albumin-creatinine ratio were significantly increased in Akita Nrf2 CONCLUSIONS/

interpretationThese findings suggest that tubular NRF2 plays an important role in the progression of diabetic kidney disease in Akita mice through modulation of the GFR and expression of SGLT2 and angiotensinogen in renal proximal tubules and tubuloglomerular feedback.

Indexed as

Akita miceGFRIntrarenal RASNRF2 KOOxidative stressRenal tubuleSGLT2

Identifiers

PMID42892652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.