Evidence map›Paper›PMID 42892651›Full record

ArticleDiabetologia2026

Prediabetes subtype-based stratification reveals distinct long-term risks for type 2 diabetes.

Hun Jee Choe, Wonsuk Choi, Howard H Chang, Dimple Kondal, K M Venkat Narayan, Joon Ho Moon, Nam H Cho

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Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Hun Jee Choe *Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.ORCID http://orcid.org/0000-0001-5318-0859
Wonsuk Choi *Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.ORCID http://orcid.org/0000-0002-0523-0839
Howard H ChangEmory Global Diabetes Research Center, Woodruff Health Sciences Center and Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6316-1640
Dimple KondalPublic Health Foundation of India, New Delhi, India.ORCID http://orcid.org/0000-0002-1417-9510
K M Venkat NarayanEmory Global Diabetes Research Center, Woodruff Health Sciences Center and Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-8621-5405
Joon Ho MoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. moonjoonho@snu.ac.kr.ORCID http://orcid.org/0000-0003-1897-0905
Nam H ChoDepartment of Preventive Medicine, Ajou University School of Medicine, Suwon, Korea. chnaha@ajou.ac.kr.ORCID http://orcid.org/0000-0003-4551-7591

Funding

Korea Centers for Disease Control and Prevention 2001-347-6111-221Korea Centers for Disease Control and Prevention 2002-347-6111-221Korea Centers for Disease Control and Prevention 2003-347-611National Research Foundation of Korea NRF-2022R1C1C1006021National Research Foundation of Korea RS-2023-00222910National Research Foundation of Korea RS-2023-00262002National Research Foundation of Korea RS-2024-004041
6 · The paper itself

Abstract

aims/hypothesisPrediabetes is heterogeneous, with subtypes defined by impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or HbA

methodsWe analysed 7186 Korean adults aged 40-69 years from the community-based Korean Genome and Epidemiology Study, who were followed for up to 20 years with biennial (every 2 years) oral glucose tolerance tests and HbA

resultsCompared with normoglycaemia, the adjusted hazard ratios (aHRs) were 5.84 (95% CI 5.03, 6.79) for IFG, 4.60 (95% CI 4.17, 5.07) for IGT, and 4.68 (95% CI 4.22, 5.19) for HbA CONCLUSIONS/

interpretationDiabetes progression differs based on both glycaemic subtype and physiological subtype. Integrating IGI and ISI with conventional definitions enhances risk stratification and may help to identify high-risk individuals for earlier targeted intervention.

Indexed as

Elevated HbA1cImpaired fasting glucoseImpaired glucose toleranceInsulin secretionInsulin sensitivityPrediabetes

Identifiers

PMID42892651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.