Evidence map›Paper›PMID 42892624›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Single-cell RNA sequencing identifies a proinflammatory S100a8/a9

Ting Ren, Xinni Zhang, Jinghan Feng, Xiaoyan Wang, Zhouping Zou, Qi Zeng, Fangyuan Peng, Qiang Yang, Xiaoqiang Ding, Ping Jia

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ting Ren *Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xinni Zhang *Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jinghan FengDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoyan WangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhouping ZouDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Qi ZengDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Fangyuan PengDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Qiang YangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoqiang DingDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China. ding.xiaoqiang@zs-hospital.sh.cn.
Ping JiaDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China. jia.ping1@zs-hospital.sh.cn.

Funding

Clinical Research Plan of SHDC SHDC2020CR2022BNational Natural Science Foundation of China grants 82170695Science and Technology Commission of Shanghai 14DZ2260200
6 · The paper itself

Abstract

objectiveMacrophages represent a heterogeneous cell population in the kidney. However, macrophage subsets and their role in endotoxemia-induced acute kidney injury (AKI) remain elucidated. MATERIAL AND

methodsSingle-cell RNA sequencing was performed to identify macrophage subpopulations in mouse kidney following lipopolysaccharide (LPS) challenge. AKI was induced by LPS treatment or renal ischemia reperfusion injury in wild-type or S100a9

resultsBy using single-cell RNA sequencing, we identified a unique S100a8/a9

conclusionsS100a8/a9 plays a regulatory role in CD11b

Indexed as

Acute Kidney InjuryCalgranulin ACalgranulin BMacrophagesAnimalsCytokinesKidneyLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutReperfusion InjurySequence Analysis, RNACalgranulin ACalgranulin BCytokinesLipopolysaccharidesS100a8 protein, mouseS100A9 protein, mouseAcute kidney injuryEndotoxemiaInflammationMacrophageS100a8/a9

Identifiers

PMID42892624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.