ReviewJournal of applied genetics2026
Bats, wild rodents, and marsupials as ecosentinels of antimicrobial resistance: a systematized narrative review of resistance genes, mobile genetic elements, and One Health implications.
Review in Journal of applied genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance (AMR) is a major One Health challenge, yet wildlife remains underrepresented in surveillance systems. This systematized narrative review synthesized studies published between 2011 and 2025 on antimicrobial-resistant bacteria in bats, wild rodents, and marsupials, aiming to evaluate their role as reservoirs, disseminators, and ecosentinels of environmental AMR. The search was conducted in PubMed, SciELO, MEDLINE, and Scopus, and original studies reporting bacterial identification and phenotypic or genotypic resistance data were included. A total of 110 studies met the inclusion criteria, comprising rodents (n = 56), bats (n = 37), and marsupials (n = 17). The most frequently reported bacterial groups included Escherichia coli, Staphylococcus spp., Klebsiella pneumoniae, Enterococcus spp., and Salmonella spp. Rodents frequently harbored multidrug-resistant Enterobacterales, including ESBL-producing E. coli and resistance genes associated with last-line antimicrobials, reflecting exposure to urban, agricultural, and waste-contaminated environments. Bats were prominent reservoirs of resistant Staphylococcus spp., including methicillin-resistant strains, and carried clinically relevant Gram-negative bacteria, likely influenced by mobility, diet, colony behavior, and anthropogenic landscape exposure. Marsupials generally showed lower AMR burdens in free-ranging conditions, but captive and rehabilitated individuals exhibited increased resistance, suggesting human-mediated acquisition and amplification. Across host groups, the detection of mobile genetic elements and resistance determinants shared with clinical contexts supports the occurrence of cross-ecosystem exchange. These findings reinforce the need to integrate wildlife into AMR monitoring frameworks as early-warning indicators of environmental contamination and resistance dissemination.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.