Evidence map›Paper›PMID 42891856›Full record

ArticleInternational ophthalmology2026

Clinical and imaging characterization of ocular toxoplasmosis in a Central-West Brazilian population.

Alexsandra Passarelli Giabardo Marques, Luiza Roschel Zaunrith, Danilo Donizete da Silva, Aparecida Perpétuo Silveira Carvalho, Fernando Henrique Antunes Murata, Rubens Camargo Siqueira, Lucas Gazarini, Edis Belini Júnior, Julie Massayo Maeda Oda, Christiane Maria Ayo and 2 more

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Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Alexsandra Passarelli Giabardo MarquesUniversidade Federal do Mato Grosso do Sul, Três Lagoas, MS, Brazil.
Luiza Roschel ZaunrithDepartment of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
Danilo Donizete da SilvaDepartment of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
Aparecida Perpétuo Silveira CarvalhoDepartment of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
Fernando Henrique Antunes MurataDepartment of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
Rubens Camargo SiqueiraDepartment of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
Lucas Gazarini *Universidade Federal do Mato Grosso do Sul, Três Lagoas, MS, Brazil.
Edis Belini JúniorUniversidade Federal do Mato Grosso do Sul, Três Lagoas, MS, Brazil.
Julie Massayo Maeda OdaUniversidade Federal do Mato Grosso do Sul, Três Lagoas, MS, Brazil.
Christiane Maria AyoDepartment of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
Luiz Carlos de MattosDepartment of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
Cinara Cássia Brandão *Department of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil. cinara.brandao@famerp.br.ORCID https://orcid.org/0000-0002-4836-3113

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 133104/2023-0 and 122474/2024-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 141527/2023-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 170007/2023-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 305976/2022-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.693830/2022-00Faculdade de Medicina de São José do Rio Preto PIBIC-FAMERPFundação de Amparo à Pesquisa do Estado de São Paulo 2020/03972-7
6 · The paper itself

Abstract

objectiveTo evaluate and characterize patients with presumed ocular toxoplasmosis using combined clinical and serological approaches in the municipality of Três Lagoas, Mato Grosso do Sul, Brazil.

methodsThis cross-sectional quantitative study included 85 patients with presumed Toxoplasma gondii related retinochoroiditis referred from the public healthcare system. Participants underwent ophthalmologic examination and serological testing for anti-T. gondii IgG and IgM antibodies. Patients were classified into control (G1), active lesion (G2), and cicatricial lesion (G3) groups.

resultsOverall, 76.5% of patients were positive for anti-T. gondii IgG, while 3.5% were positive for IgM. Most patients with cicatricial lesions (G3) were IgG-positive (31/33). In contrast, IgM positivity was restricted to a small subset of patients (3/13) with active lesions (G2). Ophthalmologic evaluation demonstrated that unilateral disease predominated (78.2%), with lesions mainly located in the posterior pole (52.8%). Morphologically, round-to-ovoid lesions were most frequent (60.0%), followed by amoeboid (16.0%), placoid (8.0%), and wedge-shaped and punctate (4.0% each) patterns. Mean lesion size among evaluable eyes was 16.2 mm

conclusionThe analyses provide data that contribute to the understanding of the clinical characteristics of the disease, ocular behavior, and serological findings. Consequently, preventive measures may be implemented, reducing risk factors and improving patients' quality of life.

Indexed as

Eye Infections, ParasiticToxoplasmaToxoplasmosis, OcularAdolescentAdultAgedAntibodies, ProtozoanBrazilChildCross-Sectional StudiesFemaleHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedAntibodies, ProtozoanImmunoglobulin GImmunoglobulin MColor fundus photographyOcular toxoplasmosisRetinal mappingSerologyToxoplasma gondii

Identifiers

PMID42891856
PMCPMC13676675

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