ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
36-month multi-centre outcomes of XEN45 gel stent implantation in Asian versus non-Asian eyes with primary open angle glaucoma.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEthnicity has been shown to influence outcomes of bleb-forming glaucoma filtering surgery. This study evaluated 3-year outcomes of XEN45 Gel Stent (XGS) in Asian versus non-Asian eyes with primary open angle glaucoma (POAG).
methodsThis multicentre, retrospective cohort included 117 eyes with POAG undergoing XGS implantation, with or without concomitant phacoemulsification, between January 2017 and March 2023. Eyes were categorized as Asian or non-Asian based on recorded ethnicity. The primary outcome was cumulative surgical success at three years using survival analyses across intraocular pressure (IOP) thresholds (≤ 18, ≤ 15, and ≤ 12 mmHg with ≥ 20% reduction from baseline). Secondary analysis incorporating a medication reduction goal was performed. Secondary outcomes included longitudinal changes in IOP and medications, predictors of time-to-failure, and postoperative interventions and complications. Longitudinal outcomes were analysed using linear mixed-effects models. Multivariable Cox proportional hazards models evaluated predictors of failure.
results92 Asian and 25 non-Asian eyes were included. Both groups demonstrated sustained reductions in IOP and medication burden over 36 months. Three-year cumulative success rates were comparable between Asian and non-Asian eyes across all success definitions (AR-18: 72.2% vs. 76.5%; AR-15: 72.7% vs. 76.5%; AR-12: 68.6% vs. 63.9%; all p > 0.30). No significant differences in cumulative success were observed between Phaco-XEN and standalone XEN procedures. Ethnicity and concomitant phacoemulsification were not independently associated with time-to-failure. Post-operative interventions and complications were infrequent.
conclusionXGS demonstrated no significant differences in 3-year surgical success, safety, and durability between broadly categorized Asian and non-Asian eyes with POAG. Neither ethnicity nor concomitant phacoemulsification independently influenced failure risk.
Indexed as
Identifiers
42891852What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.