ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Stage-dependent differences in recalculated mean deviation between 24plus(1-2) and 24plus(1) test locations in glaucoma.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate stage-dependent differences in mean deviation (MD) recalculated from the 24plus(1-2) and 24plus(1) test locations and to identify the MD range at which divergence between the reduced and full location sets exceeds a prespecified operational threshold in glaucoma.
methodsThis retrospective, cross-sectional study included 394 eyes from 197 patients with glaucoma including preperimetric glaucoma (PPG). The 24plus(1) MD was recalculated from a subset of 36 test locations derived from the 24plus(1-2) grid. Glaucoma severity was classified as PPG, early, moderate, or advanced based on MD. Differences between the full and reduced location sets were assessed using cluster-adjusted Bland-Altman analysis and linear mixed-effects models. Mixed-effects logistic regression was applied to estimate the probability of exceeding a prespecified operational MD-difference threshold (|ΔMD|> 1 dB), with patient-level bootstrap confidence intervals.
resultsThe overall mean difference in recalculated MD was - 0.52 dB (95% limits of agreement: - 2.82 to 1.78 dB). The proportion of eyes with |ΔMD|> 1 dB was 1.9% in PPG, 17.8% in early glaucoma, 50.0% in moderate glaucoma, and 67.5% in advanced glaucoma. Worse MD was significantly associated with a higher probability of exceeding the prespecified operational MD-difference threshold (β = - 0.169; P < 0.001). MD values of - 5.4 dB (95% CI: - 7.0 to - 4.0) and - 11.9 dB (95% CI: - 14.1 to - 9.9) corresponded to 25% and 50% predicted probabilities of deviation, respectively.
conclusionIn this recalculation/subsampling analysis, 24plus(1)-derived MD was similar to 24plus(1-2)-derived MD in early glaucoma but diverged with advancing disease, particularly beyond approximately - 5 to - 6 dB, suggesting caution when interpreting 24plus(1)-derived MD in more advanced glaucoma.
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