Evidence map›Paper›PMID 42891801›Full record

ReviewMolecular neurobiology2026

A Review of the Molecular Evidence for Near-Infrared Light in Astrocyte-Mediated Neurorehabilitation.

Xi Li, Ai Liu, Xing Qi, Dong Li, Duo Liu, Shuwei Liu, Qiji Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xi Li *Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. lixi@sdu.edu.cn.ORCID https://orcid.org/0000-0003-2912-5803
Ai Liu *Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Xing QiKey Laboratory of Experimental Teratology of the Ministry of Education, Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Dong LiJinan Perfect Biological Technology Co. Ltd., Jinan, China.
Duo LiuInstitute of Novel Semiconductors, State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, Shandong, China.
Shuwei LiuDepartment of Anatomy and Neurobiology, Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorder, Shandong Key Laboratory of Digital Human and Clinical Anatomy, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012, Shandong, China. liusw@sdu.edu.cn.
Qiji LiuKey Laboratory of Experimental Teratology of the Ministry of Education, Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. liuqiji@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared (NIR) light represents a promising, noninvasive therapeutic for neurological disorders, predicated on its capacity to modulate astrocyte function. As the primary glial population in the central nervous system, astrocytes are indispensable for maintaining neuronal homeostasis, regulating glutamate metabolism, and supporting metabolic energetics. This review synthesizes recent advancements in NIR-driven neurorehabilitation, elucidating the molecular signaling cascades and transduction pathways activated within the astrocytic network. We specifically examine translational applications across preclinical and clinical models of stroke, Alzheimer's disease, epilepsy, and psychiatric disorders. Furthermore, we evaluate how the integration of optogenetic tools and nanomaterials has refined NIR therapies, establishing a foundation for high-precision neurology. Given the rising demand for nonsurgical interventions, this review provides a timely framework for the next generation of photobiomodulation and neural modulation strategies.

Indexed as

AstrocytesInfrared RaysNeurological RehabilitationAnimalsHumansAstrocytesBrain disordersNIR lightPhotobiomodulationRehabilitation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.