ReviewInflammopharmacology2026
Effects of resveratrol supplementation on inflammatory and oxidative stress biomarkers in metabolic disorders: a systematic review and dose-response meta‑analysis of randomized controlled trials.
Review in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
7 authors.
Funding
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Abstract
backgroundChronic low-grade inflammation and oxidative stress are hallmarks of metabolic disorders. A naturally occurring polyphenol, resveratrol (RSV), has shown promise in modulating these pathways, however clinical evidence is mixed. To systematically review and perform a dose-response meta-analysis of randomized controlled trials (RCTs) to assess the effects of RSV supplementation on inflammatory and oxidative stress biomarkers in patients with these disorders.
methodsA systematic search up to August 2026 following PRISMA guidelines was conducted to identify RCTs that examined the effect of RSV on inflammatory (including C-reactive protein (CRP), Tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6)) and oxidative stress (malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC)) biomarkers in populations with metabolic disorders. Random effects models were used to combine the data. Dose-response relationships were evaluated using linear and non-linear modelling. Trial sequential analysis (TSA) was performed to adjust for repetitive testing, calculate the required information size (RIS), and assess the robustness of the cumulative evidence.
resultsMeta-analysis of 25 RCTs for CRP showed a statistically significant reduction (SMD = -0.18, 95% CI: -0.33 to -0.03, p = 0.0202, I
conclusionRSV supplementation is associated with a modest reduction in CRP, supported by TSA; however, effects on other inflammatory and oxidative stress biomarkers were null or inconclusive. The absence of a clear dose-response relationship and the surrogate status of CRP limit the clinical interpretability of these findings.
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Registered trials
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